Animals Published ADM's Clinical Study of Postbiotic's Impact on Oral Health Markers in Adult Dogs

CHICAGO—ADM (NYSE: ADM), a global leader in innovative solutions from nature, has announced the publication of a new study on Lactiplantibacillus plantarum CECT 9161 strain in its heat-treated postbiotic form (PRIOME® Oral Care*) in the prestigious scientific journal, Animals. The clinical trial has demonstrated that PRIOME® Oral Care postbiotic supports oral health in adult dogs by supporting a healthy oral microbiome and contributing to reduce dental plaque formation.

"Maintaining good oral hygiene in dogs is important to their overall wellness and it's a growing concern among pet owners, yet regular toothbrushing can be challenging," said Dr. Sophie Nixon, Head of R&D Clinical Research for Pet & Animal Wellbeing, ADM. "Our research highlights the potential for innovative postbiotic solutions to help support canine oral care and represents a promising step forward in identifying more convenient approaches to supporting oral health."

ADM's Research and Development team conducted a randomized, blinded, placebo-controlled clinical trial involving 60 healthy adult dogs. Following dental cleaning, the dogs were divided into three groups and fed with a dry kibble diet with either a placebo, or a low dose of PRIOME® Oral Care or a high dose of PRIOME® Oral Care, daily for 57 days. Researchers assessed dental plaque, gum health, bad breath and tartar at intervals throughout the trial, and performed an in-depth analysis of the oral microbiome.

Key findings from the trial included:
•    Dogs receiving the high dose of the postbiotic showed a significant 10% reduction in dental plaque accumulation between day 29 and day 57.
•    An overall trend toward reduced dental plaque formation was observed in the low-dose group compared to placebo.
•    Microbiome analysis showed the postbiotic may support overall oral health.

"This study marks the first canine clinical trial to suggest the effects of PRIOME® Oral Care and how it can reduce dental plaque formation in dogs and support their oral microbiome," said Peter Jüsten, Global Vice President, R&D Health & Wellness at ADM. "This scientific publication is the culmination of many years of research and development work, spanning multiple ADM teams, sites and countries, and details the full process of strain identification, pre-clinical characterization and clinical substantiation. In addition, it contributes to an expanding body of scientific evidence supporting the role of postbiotics in reinforcing pet wellness."

The full text of the study can be read in Animals here. Learn more about ADM's extensive portfolio of science-backed microbiome solutions for pets here.

*PRIOME® is a trademark registered for ADM or its affiliates in the EU and other countries.

About ADM
ADM unlocks the power of nature to enrich the quality of life. We're an essential global agricultural supply chain manager and processor, providing food security by connecting local needs with global capabilities. We're a premier human and animal nutrition provider, offering one of the industry's broadest portfolios of ingredients and solutions from nature. We're a trailblazer in health and well-being, with an industry-leading range of products for consumers looking for new ways to live healthier lives. We're a cutting-edge innovator, guiding the way to a future of new bio-based consumer and industrial solutions. And we're leading in business-driven sustainability efforts that support a strong agricultural sector, resilient supply chains, and a vast and growing bioeconomy. Around the globe, our expertise and innovation are meeting critical needs from harvest to home. Learn more at www.adm.com.

ADM Media Relations
Jackie Anderson
media@adm.com
312-634-8484