ADM's DE111 Gut Health Probiotic Approved by the National Health Commission (NHC) in China

ADM's DE111 Gut Health Probiotic Approved by the National Health Commission (NHC) in China


This approval is a testament to the depth of research demonstrating DE111TM spore-forming probiotic's quality and safety. 

SHANGHAI – ADM (NYSE: ADM), a global leader in human and animal nutrition, today announced its spore-forming probiotic DE111TM (Bacillus subtilis) has been officially approved by the National Health Commission (NHC) in China.

With the approval from NHC, Chinese customers now have access to DE111TM, knowing that the probiotic has undergone rigorous evaluation and meets China’s stringent quality and safety requirements. 

"ADM is committed to providing innovative functional ingredients and solutions that meet the highest regulatory standards and which meet the legislative criteria in China, and worldwide," said Helen Hu, president of health & wellness APAC at ADM. "The approval process required by governmental authorities are rigorous and thorough, and this achievement is a significant milestone in our market development. ADM is the first and only provider of the Bacillus subtilis food ingredient to the Chinese market."

"China is projecting substantial growth opportunities for biotics," continued Hu. "This is in part due to the country's drive towards innovation, in addition to its strong population, economy and history of focusing on preventative wellness solutions. With the approval of DE111TM, we can empower individuals across the globe to proactively manage their wellness goals with our science-backed gut health microbiome-supporting solutions."

DE111TM has clinically documented results showing that it supports digestive health1 and healthy immune function2,3. It can also survive through the stomach and germinate in the small intestine4 and supplementing with DE111TM can support a healthy gastrointestinal (GI) tract, gut function and microbiome diversity within the gut. As a spore-forming probiotic DE111TM retains functionality through challenging processing conditions, that may otherwise damage conventional probiotics, and is shelf stable, which makes it suitable for a wide range of different foods, beverages, and dietary supplements*.

According to an FMCG Gurus study, 78% of Chinese consumers recognize the link between their digestive health and overall well-being, and 78% find food and drink products positioned around improving digestive health appealing5. Further, 57% of Chinese consumers have used probiotics/cultures to address digestive health concerns over the past 12 months5. This focus on digestive health and probiotics coincides with the predicted growth of the Chinese probiotic supplement market, with a forecasted CAGR of 11.7% between 2021 and 20266.

ADM expanded its health and wellness solutions library to include DE111TM following the company's acquisition of Deerland Probiotics & Enzymes in 2021. Through ADM's global reach, the availability and approval of DE111TM is now widespread. For more information about DE111TM and ADM's microbiome solutions library, please visit

Local regulations must be reviewed to confirm permissibility of ingredients for each food category.

1Labellarte, G., et al. (2019) Food and Nutrition Sciences, 10, 626-634

2Freedman, K.E., et al. (2021) Int. J. Mol. Sci. 2021, 22, 2453

3Townsend, J., et al. (2018) Sports, 6(3), 70

4Colom J.; et al. (2021) Front. Microbiol., 12:715863

5FMCG Gurus, Digestive Health Global Study, 2022

6ADM Outside Voice, Probiotics/Postbiotics Market Research in China, 2022

About ADM
ADM unlocks the power of nature to enrich the quality of life. We’re an essential global agricultural supply chain manager and processor, providing food security by connecting local needs with global capabilities. We’re a premier human and animal nutrition provider, offering one of the industry’s broadest portfolios of ingredients and solutions from nature. We’re a trailblazer in health and well-being, with an industry-leading range of products for consumers looking for new ways to live healthier lives. We’re a cutting-edge innovator, guiding the way to a future of new consumer and industrial solutions. And we're a leader in sustainability, scaling across entire value chains to help decarbonize the multiple industries we serve. Around the globe, our innovation and expertise are meeting critical needs while nourishing quality of life and supporting a healthier planet. Learn more at  

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Jackie Anderson